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NF1 mutations in 1 Chronic lymphocytic leukemia project possibly contribute to the detection of the gene in the PAN-cancer anlaysis:

Chronic lymphocytic leukemia
Projects 2
290 Samples
Coding sequence mutations (CSMs)
in driver genes 280
in all genes 49201
Protein affecting mutations (PAMs)
in driver genes 213
in all genes 4046
NF1
Ensembl id ENSG00000196712
Mutated samples
Coding Sequence 10 (3.4%)
Protein Affecting 4 (1.4%)
Mode of action Loss of function
Known driver Yes
Project Signals
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Chronic lymphocytic leukemia projects in all NF1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Chronic Lymphocytic Leukemia Spain Yes 8 3 1.03
Chronic Lymphocytic Leukemia Broad No 2 1 0.34
The mutations needle plot shows the distribution of the observed NF1 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification