Top
NF1 is detected as a mutational cancer driver in 1 Breast carcinoma project and in the PAN-cancer analysis

Breast carcinoma
Projects 6
1148 Samples
Coding sequence mutations (CSMs)
in driver genes 2330
in all genes 84945
Protein affecting mutations (PAMs)
in driver genes 2121
in all genes 45048
NF1
Ensembl id ENSG00000196712
Mutated samples
Coding Sequence 29 (2.5%)
Protein Affecting 24 (2.1%)
Mode of action Loss of function
Known driver Yes
Project Signals
BRCA_TCGA F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Breast carcinoma projects in all NF1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast invasive carcinoma TCGA Yes 21 19 1.66
Breast Cancer Sanger Institute Yes 5 3 0.26
ER positive Breast cancer Washington University No 2 1 0.09
Breast Cancer Johns Hopkins University No 1 1 0.09
The mutations needle plot shows the distribution of the observed NF1 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification