Top
NEB has not been detected as a mutational cancer driver

NEB
Ensembl id ENSG00000183091
Mutated samples
Coding Sequence 386 (5.7%)
Protein Affecting 300 (4.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NEB gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 112 81 21.95
Breast carcinoma No 33 28 2.44
Head and neck squamous cell carcinoma No 33 28 7.47
Lung squamous cell carcinoma No 32 25 14.37
Lung adenocarcinoma No 31 24 6.14
Uterine corpus endometrioid carcinoma No 24 23 10.00
Stomach adenocarcinoma No 19 15 9.32
Renal clear cell carcinoma No 16 12 2.88
Bladder carcinoma No 14 11 11.22
Esophageal carcinoma No 12 9 6.16
Serous ovarian adenocarcinoma No 9 7 2.22
Lower grade glioma No 8 6 3.55
Glioblastoma multiforme No 9 6 1.58
Pancreas adenocarcinoma No 5 4 1.87
Colorectal adenocarcinoma No 7 4 1.75
Prostate adenocarcinoma No 3 3 1.23
Hepatocarcinoma No 3 3 3.33
Multiple myeloma No 4 3 4.35
Medulloblastoma No 2 2 0.95
Small cell lung carcinoma No 2 2 2.90
Acute myeloid leukemia No 1 1 0.51
Thyroid carcinoma No 2 1 0.31
Chronic lymphocytic leukemia No 4 1 0.34
Acute lymphocytic leukemia No 1 1 0.82
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence