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NCKAP5 has not been detected as a mutational cancer driver

NCKAP5
Ensembl id ENSG00000176771
Mutated samples
Coding Sequence 234 (3.4%)
Protein Affecting 166 (2.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NCKAP5 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 68 53 14.36
Lung adenocarcinoma No 29 25 6.39
Lung squamous cell carcinoma No 16 12 6.90
Breast carcinoma No 16 9 0.78
Stomach adenocarcinoma No 11 9 5.59
Uterine corpus endometrioid carcinoma No 10 8 3.48
Head and neck squamous cell carcinoma No 11 8 2.13
Esophageal carcinoma No 10 8 5.48
Colorectal adenocarcinoma No 6 6 2.62
Bladder carcinoma No 7 5 5.10
Prostate adenocarcinoma No 4 4 1.65
Serous ovarian adenocarcinoma No 5 4 1.27
Renal clear cell carcinoma No 4 3 0.72
Lower grade glioma No 3 3 1.78
Chronic lymphocytic leukemia No 23 2 0.69
Glioblastoma multiforme No 3 2 0.53
Hepatocarcinoma No 2 1 1.11
Acute myeloid leukemia No 1 1 0.51
Pancreas adenocarcinoma No 1 1 0.47
Multiple myeloma No 1 1 1.45
Diffuse B cell lymphoma No 1 1 4.35
Medulloblastoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence