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NBAS has not been detected as a mutational cancer driver

NBAS
Ensembl id ENSG00000151779
Mutated samples
Coding Sequence 158 (2.3%)
Protein Affecting 119 (1.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NBAS gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 30 24 6.50
Lung adenocarcinoma No 20 14 3.58
Breast carcinoma No 13 13 1.13
Head and neck squamous cell carcinoma No 16 12 3.20
Lung squamous cell carcinoma No 14 9 5.17
Stomach adenocarcinoma No 9 8 4.97
Small cell lung carcinoma No 7 7 10.14
Medulloblastoma No 4 4 1.90
Renal clear cell carcinoma No 4 4 0.96
Glioblastoma multiforme No 4 4 1.06
Pancreas adenocarcinoma No 3 3 1.40
Esophageal carcinoma No 3 3 2.05
Prostate adenocarcinoma No 4 2 0.82
Hepatocarcinoma No 2 2 2.22
Neuroblastoma No 2 2 0.95
Uterine corpus endometrioid carcinoma No 2 2 0.87
Bladder carcinoma No 2 1 1.02
Non small cell lung carcinoma No 2 1 3.23
Multiple myeloma No 2 1 1.45
Lower grade glioma No 2 1 0.59
Serous ovarian adenocarcinoma No 2 1 0.32
Colorectal adenocarcinoma No 3 1 0.44
Acute myeloid leukemia No 1 0 0.00
Chronic lymphocytic leukemia No 5 0 0.00
Pylocytic astrocytoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence