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MUC20 mutations in 4 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Breast carcinoma, Lung squamous cell carcinoma, Uterine corpus endometrioid carcinoma, Head and neck squamous cell carcinoma

MUC20
Ensembl id ENSG00000176945
Mutated samples
Coding Sequence 98 (1.4%)
Protein Affecting 30 (0.4%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MUC20 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung squamous cell carcinoma Yes 5 4 2.30
Head and neck squamous cell carcinoma Yes 14 3 0.80
Breast carcinoma Yes 4 2 0.17
Uterine corpus endometrioid carcinoma Yes 3 2 0.87
Cutaneous melanoma No 25 12 3.25
Lung adenocarcinoma No 3 1 0.26
Hepatocarcinoma No 2 1 1.11
Bladder carcinoma No 5 1 1.02
Thyroid carcinoma No 6 1 0.31
Stomach adenocarcinoma No 2 1 0.62
Diffuse B cell lymphoma No 1 1 4.35
Esophageal carcinoma No 3 1 0.68
Prostate adenocarcinoma No 7 0 0.00
Renal clear cell carcinoma No 5 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Lower grade glioma No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
Glioblastoma multiforme No 7 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence