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MTOR is detected as a mutational cancer driver in 1 cancer type: Renal clear cell carcinoma and in the PAN-cancer analysis

MTOR
Ensembl id ENSG00000198793
Mutated samples
Coding Sequence 197 (2.9%)
Protein Affecting 146 (2.1%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
RCCC FR
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MTOR gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Renal clear cell carcinoma Yes 29 25 6.00
Breast carcinoma Yes 19 15 1.31
Head and neck squamous cell carcinoma Yes 8 6 1.60
Small cell lung carcinoma Yes 5 5 7.25
Chronic lymphocytic leukemia Yes 3 3 1.03
Esophageal carcinoma Yes 5 3 2.05
Bladder carcinoma Yes 2 2 2.04
Lower grade glioma Yes 2 2 1.18
Cutaneous melanoma No 34 21 5.69
Lung adenocarcinoma No 20 17 4.35
Uterine corpus endometrioid carcinoma No 15 12 5.22
Lung squamous cell carcinoma No 12 8 4.60
Stomach adenocarcinoma No 12 8 4.97
Colorectal adenocarcinoma No 7 7 3.06
Serous ovarian adenocarcinoma No 6 6 1.90
Glioblastoma multiforme No 4 4 1.06
Prostate adenocarcinoma No 2 1 0.41
Non small cell lung carcinoma No 4 1 3.23
Hepatocarcinoma No 2 0 0.00
Medulloblastoma No 1 0 0.00
Multiple myeloma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence