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MORC1 has not been detected as a mutational cancer driver

MORC1
Ensembl id ENSG00000114487
Mutated samples
Coding Sequence 179 (2.6%)
Protein Affecting 131 (1.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MORC1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 80 63 17.07
Breast carcinoma No 12 10 0.87
Lung squamous cell carcinoma No 14 9 5.17
Small cell lung carcinoma No 9 9 13.04
Head and neck squamous cell carcinoma No 11 9 2.40
Bladder carcinoma No 6 6 6.12
Lung adenocarcinoma No 8 5 1.28
Glioblastoma multiforme No 6 5 1.32
Uterine corpus endometrioid carcinoma No 6 3 1.30
Stomach adenocarcinoma No 4 3 1.86
Colorectal adenocarcinoma No 5 3 1.31
Prostate adenocarcinoma No 4 2 0.82
Renal clear cell carcinoma No 1 1 0.24
Non small cell lung carcinoma No 4 1 3.23
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 2 1 0.32
Hepatocarcinoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence