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MLPH has not been detected as a mutational cancer driver

MLPH
Ensembl id ENSG00000115648
Mutated samples
Coding Sequence 42 (0.6%)
Protein Affecting 26 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MLPH gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 12 8 2.17
Lung squamous cell carcinoma No 4 3 1.72
Uterine corpus endometrioid carcinoma No 3 3 1.30
Small cell lung carcinoma No 2 2 2.90
Colorectal adenocarcinoma No 2 2 0.87
Esophageal carcinoma No 4 2 1.37
Lung adenocarcinoma No 2 1 0.26
Hepatocarcinoma No 1 1 1.11
Bladder carcinoma No 1 1 1.02
Breast carcinoma No 2 1 0.09
Renal clear cell carcinoma No 1 1 0.24
Serous ovarian adenocarcinoma No 1 1 0.32
Chronic lymphocytic leukemia No 1 0 0.00
Lower grade glioma No 1 0 0.00
Pylocytic astrocytoma No 2 0 0.00
Stomach adenocarcinoma No 1 0 0.00
Head and neck squamous cell carcinoma No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence