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MKNK1 has not been detected as a mutational cancer driver

MKNK1
Ensembl id ENSG00000079277
Mutated samples
Coding Sequence 39 (0.6%)
Protein Affecting 18 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MKNK1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 17 6 1.63
Lung adenocarcinoma No 5 4 1.02
Small cell lung carcinoma No 2 2 2.90
Bladder carcinoma No 1 1 1.02
Renal clear cell carcinoma No 2 1 0.24
Uterine corpus endometrioid carcinoma No 1 1 0.43
Serous ovarian adenocarcinoma No 1 1 0.32
Stomach adenocarcinoma No 2 1 0.62
Head and neck squamous cell carcinoma No 2 1 0.27
Medulloblastoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence