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METAP1 has not been detected as a mutational cancer driver

METAP1
Ensembl id ENSG00000164024
Mutated samples
Coding Sequence 21 (0.3%)
Protein Affecting 17 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all METAP1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Uterine corpus endometrioid carcinoma No 4 3 1.30
Lung adenocarcinoma No 2 2 0.51
Breast carcinoma No 2 2 0.17
Lung squamous cell carcinoma No 2 2 1.15
Cutaneous melanoma No 3 2 0.54
Bladder carcinoma No 1 1 1.02
Renal clear cell carcinoma No 1 1 0.24
Chronic lymphocytic leukemia No 1 1 0.34
Stomach adenocarcinoma No 1 1 0.62
Small cell lung carcinoma No 1 1 1.45
Head and neck squamous cell carcinoma No 1 1 0.27
Pylocytic astrocytoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence