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MERTK has not been detected as a mutational cancer driver

MERTK
Ensembl id ENSG00000153208
Mutated samples
Coding Sequence 90 (1.3%)
Protein Affecting 66 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MERTK gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 35 23 6.23
Lung adenocarcinoma No 15 11 2.81
Head and neck squamous cell carcinoma No 6 6 1.60
Bladder carcinoma No 5 5 5.10
Breast carcinoma No 5 4 0.35
Lung squamous cell carcinoma No 3 2 1.15
Neuroblastoma No 2 2 0.95
Uterine corpus endometrioid carcinoma No 2 2 0.87
Chronic lymphocytic leukemia No 3 2 0.69
Stomach adenocarcinoma No 2 2 1.24
Colorectal adenocarcinoma No 2 2 0.87
Glioblastoma multiforme No 2 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Renal clear cell carcinoma No 1 1 0.24
Esophageal carcinoma No 2 1 0.68
Hepatocarcinoma No 2 0 0.00
Medulloblastoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence