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MECOM is detected as a mutational cancer driver in 2 cancer types: Bladder carcinoma, Cutaneous melanoma and in the PAN-cancer analysis

MECOM
Ensembl id ENSG00000085276
Mutated samples
Coding Sequence 189 (2.8%)
Protein Affecting 142 (2.1%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
BLCA F
CM F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MECOM gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 82 67 18.16
Breast carcinoma Yes 13 10 0.87
Bladder carcinoma Yes 5 5 5.10
Stomach adenocarcinoma Yes 8 5 3.11
Prostate adenocarcinoma Yes 4 3 1.23
Lower grade glioma Yes 3 3 1.78
Neuroblastoma Yes 2 2 0.95
Multiple myeloma Yes 2 2 2.90
Serous ovarian adenocarcinoma Yes 2 2 0.63
Colorectal adenocarcinoma Yes 3 2 0.87
Lung adenocarcinoma No 10 9 2.30
Lung squamous cell carcinoma No 10 8 4.60
Uterine corpus endometrioid carcinoma No 9 7 3.04
Head and neck squamous cell carcinoma No 11 5 1.33
Glioblastoma multiforme No 9 5 1.32
Renal clear cell carcinoma No 4 4 0.96
Hepatocarcinoma No 3 1 1.11
Non small cell lung carcinoma No 1 1 3.23
Small cell lung carcinoma No 1 1 1.45
Pancreas adenocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 6 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence