Top
MCM6 has not been detected as a mutational cancer driver

MCM6
Ensembl id ENSG00000076003
Mutated samples
Coding Sequence 62 (0.9%)
Protein Affecting 33 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MCM6 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 11 8 2.05
Cutaneous melanoma No 14 5 1.36
Lung squamous cell carcinoma No 5 3 1.72
Glioblastoma multiforme No 4 3 0.79
Breast carcinoma No 2 2 0.17
Renal clear cell carcinoma No 3 2 0.48
Uterine corpus endometrioid carcinoma No 5 2 0.87
Head and neck squamous cell carcinoma No 3 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 2 1 1.11
Bladder carcinoma No 3 1 1.02
Neuroblastoma No 1 1 0.48
Stomach adenocarcinoma No 5 1 0.62
Colorectal adenocarcinoma No 1 1 0.44
Medulloblastoma No 1 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence