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MAST2 has not been detected as a mutational cancer driver

MAST2
Ensembl id ENSG00000086015
Mutated samples
Coding Sequence 73 (1.1%)
Protein Affecting 61 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MAST2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 17 12 3.25
Lung adenocarcinoma No 7 7 1.79
Breast carcinoma No 7 6 0.52
Head and neck squamous cell carcinoma No 5 5 1.33
Lung squamous cell carcinoma No 4 4 2.30
Serous ovarian adenocarcinoma No 4 4 1.27
Esophageal carcinoma No 4 4 2.74
Thyroid carcinoma No 3 3 0.93
Lower grade glioma No 3 3 1.78
Small cell lung carcinoma No 3 3 4.35
Prostate adenocarcinoma No 4 2 0.82
Renal clear cell carcinoma No 2 2 0.48
Bladder carcinoma No 1 1 1.02
Pancreas adenocarcinoma No 1 1 0.47
Neuroblastoma No 1 1 0.48
Stomach adenocarcinoma No 1 1 0.62
Colorectal adenocarcinoma No 2 1 0.44
Glioblastoma multiforme No 1 1 0.26
Chronic lymphocytic leukemia No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence