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MAP4K4 has not been detected as a mutational cancer driver

MAP4K4
Ensembl id ENSG00000071054
Mutated samples
Coding Sequence 63 (0.9%)
Protein Affecting 46 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MAP4K4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 17 12 3.25
Lung squamous cell carcinoma No 9 6 3.45
Breast carcinoma No 4 4 0.35
Head and neck squamous cell carcinoma No 4 4 1.07
Uterine corpus endometrioid carcinoma No 3 3 1.30
Stomach adenocarcinoma No 4 3 1.86
Glioblastoma multiforme No 4 3 0.79
Bladder carcinoma No 2 2 2.04
Multiple myeloma No 4 2 2.90
Lung adenocarcinoma No 1 1 0.26
Renal clear cell carcinoma No 3 1 0.24
Thyroid carcinoma No 1 1 0.31
Chronic lymphocytic leukemia No 1 1 0.34
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Esophageal carcinoma No 1 1 0.68
Hepatocarcinoma No 2 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence