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MAP4K3 mutations in 6 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Lung adenocarcinoma, Bladder carcinoma, Cutaneous melanoma, Serous ovarian adenocarcinoma, Head and neck squamous cell carcinoma, Glioblastoma multiforme

MAP4K3
Ensembl id ENSG00000011566
Mutated samples
Coding Sequence 69 (1.0%)
Protein Affecting 56 (0.8%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MAP4K3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 14 9 2.44
Head and neck squamous cell carcinoma Yes 8 7 1.87
Lung adenocarcinoma Yes 6 5 1.28
Serous ovarian adenocarcinoma Yes 4 4 1.27
Bladder carcinoma Yes 4 3 3.06
Glioblastoma multiforme Yes 3 3 0.79
Lung squamous cell carcinoma No 6 6 3.45
Breast carcinoma No 5 4 0.35
Renal clear cell carcinoma No 4 4 0.96
Uterine corpus endometrioid carcinoma No 5 4 1.74
Stomach adenocarcinoma No 2 2 1.24
Small cell lung carcinoma No 2 2 2.90
Pancreas adenocarcinoma No 1 1 0.47
Colorectal adenocarcinoma No 1 1 0.44
Diffuse B cell lymphoma No 1 1 4.35
Chronic lymphocytic leukemia No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence