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MACF1 is detected as a mutational cancer driver in 1 cancer type: Head and neck squamous cell carcinoma and in the PAN-cancer analysis

MACF1
Ensembl id ENSG00000127603
Mutated samples
Coding Sequence 390 (5.7%)
Protein Affecting 265 (3.9%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
HNSC F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all MACF1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma Yes 41 33 2.87
Head and neck squamous cell carcinoma Yes 34 29 7.73
Stomach adenocarcinoma Yes 22 15 9.32
Neuroblastoma Yes 4 3 1.43
Esophageal carcinoma Yes 6 3 2.05
Hepatocarcinoma Yes 6 2 2.22
Cutaneous melanoma No 68 43 11.65
Lung squamous cell carcinoma No 41 27 15.52
Lung adenocarcinoma No 33 21 5.37
Uterine corpus endometrioid carcinoma No 26 19 8.26
Bladder carcinoma No 22 14 14.29
Renal clear cell carcinoma No 20 12 2.88
Glioblastoma multiforme No 14 11 2.90
Serous ovarian adenocarcinoma No 14 10 3.16
Small cell lung carcinoma No 9 9 13.04
Colorectal adenocarcinoma No 8 7 3.06
Prostate adenocarcinoma No 9 4 1.65
Thyroid carcinoma No 3 1 0.31
Non small cell lung carcinoma No 1 1 3.23
Chronic lymphocytic leukemia No 3 1 0.34
Medulloblastoma No 1 0 0.00
Multiple myeloma No 2 0 0.00
Lower grade glioma No 2 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence