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LRRC8D has not been detected as a mutational cancer driver

LRRC8D
Ensembl id ENSG00000171492
Mutated samples
Coding Sequence 45 (0.7%)
Protein Affecting 31 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LRRC8D gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 12 9 2.44
Lung adenocarcinoma No 4 3 0.77
Small cell lung carcinoma No 3 3 4.35
Bladder carcinoma No 3 2 2.04
Breast carcinoma No 3 2 0.17
Lung squamous cell carcinoma No 2 2 1.15
Renal clear cell carcinoma No 2 2 0.48
Colorectal adenocarcinoma No 3 2 0.87
Head and neck squamous cell carcinoma No 3 2 0.53
Non small cell lung carcinoma No 1 1 3.23
Lower grade glioma No 2 1 0.59
Serous ovarian adenocarcinoma No 2 1 0.32
Stomach adenocarcinoma No 1 1 0.62
Hepatocarcinoma No 1 0 0.00
Uterine corpus endometrioid carcinoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence