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LRRC7 has not been detected as a mutational cancer driver

LRRC7
Ensembl id ENSG00000033122
Mutated samples
Coding Sequence 279 (4.1%)
Protein Affecting 189 (2.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LRRC7 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 59 41 11.11
Lung adenocarcinoma No 29 26 6.65
Lung squamous cell carcinoma No 30 26 14.94
Breast carcinoma No 18 11 0.96
Head and neck squamous cell carcinoma No 17 11 2.93
Bladder carcinoma No 11 9 9.18
Small cell lung carcinoma No 9 9 13.04
Serous ovarian adenocarcinoma No 9 8 2.53
Esophageal carcinoma No 11 8 5.48
Uterine corpus endometrioid carcinoma No 11 6 2.61
Colorectal adenocarcinoma No 8 6 2.62
Glioblastoma multiforme No 8 6 1.58
Non small cell lung carcinoma No 5 5 16.13
Stomach adenocarcinoma No 12 5 3.11
Renal clear cell carcinoma No 7 3 0.72
Prostate adenocarcinoma No 3 2 0.82
Hepatocarcinoma No 4 2 2.22
Neuroblastoma No 2 2 0.95
Thyroid carcinoma No 1 1 0.31
Chronic lymphocytic leukemia No 16 1 0.34
Lower grade glioma No 2 1 0.59
Acute myeloid leukemia No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Multiple myeloma No 1 0 0.00
Pylocytic astrocytoma No 3 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence