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LRP2 has not been detected as a mutational cancer driver

LRP2
Ensembl id ENSG00000081479
Mutated samples
Coding Sequence 406 (6.0%)
Protein Affecting 324 (4.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LRP2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 83 66 17.89
Breast carcinoma No 34 29 2.53
Lung squamous cell carcinoma No 37 29 16.67
Lung adenocarcinoma No 35 28 7.16
Head and neck squamous cell carcinoma No 34 23 6.13
Glioblastoma multiforme No 23 22 5.80
Stomach adenocarcinoma No 25 19 11.80
Colorectal adenocarcinoma No 19 17 7.42
Uterine corpus endometrioid carcinoma No 20 16 6.96
Serous ovarian adenocarcinoma No 15 15 4.75
Renal clear cell carcinoma No 16 12 2.88
Esophageal carcinoma No 15 12 8.22
Bladder carcinoma No 9 8 8.16
Chronic lymphocytic leukemia No 13 7 2.41
Small cell lung carcinoma No 6 6 8.70
Lower grade glioma No 5 4 2.37
Prostate adenocarcinoma No 4 2 0.82
Hepatocarcinoma No 2 2 2.22
Acute lymphocytic leukemia No 3 2 1.64
Medulloblastoma No 1 1 0.48
Pancreas adenocarcinoma No 1 1 0.47
Thyroid carcinoma No 2 1 0.31
Neuroblastoma No 2 1 0.48
Multiple myeloma No 1 1 1.45
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence