IntOGen - LRP1B gene cancer mutations in LUAD

LRP1B is detected as a mutational cancer driver in Lung Adenocarcinoma

LRP1B reports in Lung Adenocarcinoma (LUAD)

Methods
Mutation distribution

Cancer type details

Lung Adenocarcinoma
Cohorts 6 Samples 1,215 Mutations 1,839,527 Driver genes 76

Gene details

LRP1B
Ensembl ID ENSG00000168702 Transcript ID ENST00000389484 Protein ID ENSP00000374135
Cohorts where is driver 3 Mutated samples 107 Mutated samples (%) 8.81 Mutations 497
Mode of action Ambiguous
Known driver True

Method signals per Cohort

Cohort	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Highlight in X-axis:

Mutation (GRCh38)	Protein Position	Samples	Samples (%)	Consequence