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LRBA has not been detected as a mutational cancer driver

LRBA
Ensembl id ENSG00000198589
Mutated samples
Coding Sequence 196 (2.9%)
Protein Affecting 121 (1.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LRBA gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 52 33 8.94
Breast carcinoma No 25 19 1.66
Lung squamous cell carcinoma No 14 11 6.32
Head and neck squamous cell carcinoma No 14 8 2.13
Uterine corpus endometrioid carcinoma No 15 7 3.04
Lung adenocarcinoma No 14 6 1.53
Stomach adenocarcinoma No 8 6 3.73
Bladder carcinoma No 5 4 4.08
Renal clear cell carcinoma No 5 4 0.96
Serous ovarian adenocarcinoma No 5 4 1.27
Colorectal adenocarcinoma No 6 4 1.75
Glioblastoma multiforme No 3 3 0.79
Esophageal carcinoma No 4 3 2.05
Multiple myeloma No 3 2 2.90
Small cell lung carcinoma No 2 2 2.90
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 3 1 1.11
Acute myeloid leukemia No 1 1 0.51
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 11 1 0.34
Non small cell lung carcinoma No 1 0 0.00
Lower grade glioma No 1 0 0.00
Pylocytic astrocytoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence