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LEPR has not been detected as a mutational cancer driver

LEPR
Ensembl id ENSG00000116678
Mutated samples
Coding Sequence 132 (1.9%)
Protein Affecting 89 (1.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LEPR gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 46 29 7.86
Lung squamous cell carcinoma No 19 15 8.62
Lung adenocarcinoma No 15 12 3.07
Head and neck squamous cell carcinoma No 12 9 2.40
Breast carcinoma No 4 4 0.35
Small cell lung carcinoma No 4 4 5.80
Colorectal adenocarcinoma No 4 3 1.31
Uterine corpus endometrioid carcinoma No 3 2 0.87
Stomach adenocarcinoma No 3 2 1.24
Prostate adenocarcinoma No 1 1 0.41
Bladder carcinoma No 2 1 1.02
Renal clear cell carcinoma No 1 1 0.24
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 2 1 1.45
Serous ovarian adenocarcinoma No 1 1 0.32
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 3 1 0.68
Hepatocarcinoma No 3 0 0.00
Chronic lymphocytic leukemia No 5 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence