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LAMB3 has not been detected as a mutational cancer driver

LAMB3
Ensembl id ENSG00000196878
Mutated samples
Coding Sequence 120 (1.8%)
Protein Affecting 70 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all LAMB3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 42 23 6.23
Lung adenocarcinoma No 9 7 1.79
Stomach adenocarcinoma No 10 7 4.35
Glioblastoma multiforme No 8 7 1.85
Breast carcinoma No 10 6 0.52
Colorectal adenocarcinoma No 4 3 1.31
Head and neck squamous cell carcinoma No 4 3 0.80
Bladder carcinoma No 3 2 2.04
Lung squamous cell carcinoma No 6 2 1.15
Uterine corpus endometrioid carcinoma No 4 2 0.87
Esophageal carcinoma No 3 2 1.37
Prostate adenocarcinoma No 2 1 0.41
Renal clear cell carcinoma No 4 1 0.24
Non small cell lung carcinoma No 1 1 3.23
Chronic lymphocytic leukemia No 1 1 0.34
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 3 1 1.45
Hepatocarcinoma No 2 0 0.00
Acute myeloid leukemia No 1 0 0.00
Medulloblastoma No 1 0 0.00
Neuroblastoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence