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KRAS is detected as a mutational cancer driver in 2 Colorectal adenocarcinoma projects

Colorectal adenocarcinoma
Projects 2
229 Samples
Coding sequence mutations (CSMs)
in driver genes 955
in all genes 29233
Protein affecting mutations (PAMs)
in driver genes 905
in all genes 15873
KRAS
Ensembl id ENSG00000133703
Mutated samples
Coding Sequence 103 (45.0%)
Protein Affecting 103 (45.0%)
Mode of action Activating
Known driver Yes
Project Signals
COREAD_TCGA RFC
COREAD_JHU FC
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Colorectal adenocarcinoma projects in all KRAS gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Colorectal adenocarcinoma TCGA Yes 87 87 37.99
Colorectal adenocarcinoma Johns Hopkins University Yes 16 16 6.99
The mutations needle plot shows the distribution of the observed KRAS cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification