IntOGen - KNL1 gene cancer mutations

KNL1 is detected as a mutational cancer driver

KNL1 reports

Methods
Mutation distribution

Gene details

KNL1
Ensembl ID ENSG00000137812 Transcript ID ENST00000346991 Protein ID ENSP00000335463
Cancer types where is driver 3 Cohorts where is driver 3 Mutated samples 29 Mutations 586
Mode of action Loss of function
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence