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KLHL6 has not been detected as a mutational cancer driver

KLHL6
Ensembl id ENSG00000172578
Mutated samples
Coding Sequence 69 (1.0%)
Protein Affecting 36 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all KLHL6 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 18 9 2.44
Lung adenocarcinoma No 8 6 1.53
Bladder carcinoma No 7 4 4.08
Breast carcinoma No 4 2 0.17
Chronic lymphocytic leukemia No 5 2 0.69
Serous ovarian adenocarcinoma No 2 2 0.63
Head and neck squamous cell carcinoma No 4 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 4 1 1.11
Lung squamous cell carcinoma No 2 1 0.57
Neuroblastoma No 1 1 0.48
Multiple myeloma No 1 1 1.45
Stomach adenocarcinoma No 2 1 0.62
Colorectal adenocarcinoma No 1 1 0.44
Diffuse B cell lymphoma No 1 1 4.35
Glioblastoma multiforme No 1 1 0.26
Medulloblastoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Renal clear cell carcinoma No 2 0 0.00
Uterine corpus endometrioid carcinoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence