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KLHL2 has not been detected as a mutational cancer driver

KLHL2
Ensembl id ENSG00000109466
Mutated samples
Coding Sequence 43 (0.6%)
Protein Affecting 27 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all KLHL2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Prostate adenocarcinoma No 3 3 1.23
Lung adenocarcinoma No 3 3 0.77
Uterine corpus endometrioid carcinoma No 4 3 1.30
Stomach adenocarcinoma No 5 3 1.86
Cutaneous melanoma No 8 2 0.54
Esophageal carcinoma No 3 2 1.37
Hepatocarcinoma No 1 1 1.11
Bladder carcinoma No 1 1 1.02
Acute myeloid leukemia No 1 1 0.51
Breast carcinoma No 1 1 0.09
Lung squamous cell carcinoma No 1 1 0.57
Renal clear cell carcinoma No 1 1 0.24
Non small cell lung carcinoma No 1 1 3.23
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Head and neck squamous cell carcinoma No 4 1 0.27
Diffuse B cell lymphoma No 2 1 4.35
Chronic lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence