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KIF21B has not been detected as a mutational cancer driver

KIF21B
Ensembl id ENSG00000116852
Mutated samples
Coding Sequence 154 (2.3%)
Protein Affecting 98 (1.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all KIF21B gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 56 30 8.13
Breast carcinoma No 13 10 0.87
Lung adenocarcinoma No 13 9 2.30
Uterine corpus endometrioid carcinoma No 10 7 3.04
Lung squamous cell carcinoma No 6 6 3.45
Head and neck squamous cell carcinoma No 10 6 1.60
Small cell lung carcinoma No 5 5 7.25
Stomach adenocarcinoma No 4 4 2.48
Prostate adenocarcinoma No 4 3 1.23
Bladder carcinoma No 5 3 3.06
Renal clear cell carcinoma No 5 3 0.72
Colorectal adenocarcinoma No 4 3 1.31
Serous ovarian adenocarcinoma No 3 2 0.63
Hepatocarcinoma No 5 1 1.11
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 3 1 3.23
Chronic lymphocytic leukemia No 1 1 0.34
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 3 1 0.68
Medulloblastoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence