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KIF1A has not been detected as a mutational cancer driver

KIF1A
Ensembl id ENSG00000130294
Mutated samples
Coding Sequence 121 (1.8%)
Protein Affecting 90 (1.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all KIF1A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 29 19 5.15
Lung adenocarcinoma No 11 9 2.30
Uterine corpus endometrioid carcinoma No 12 9 3.91
Breast carcinoma No 9 8 0.70
Head and neck squamous cell carcinoma No 9 7 1.87
Renal clear cell carcinoma No 6 5 1.20
Stomach adenocarcinoma No 7 5 3.11
Bladder carcinoma No 5 4 4.08
Lung squamous cell carcinoma No 6 4 2.30
Colorectal adenocarcinoma No 5 4 1.75
Prostate adenocarcinoma No 3 2 0.82
Thyroid carcinoma No 2 2 0.62
Chronic lymphocytic leukemia No 3 2 0.69
Lower grade glioma No 2 2 1.18
Small cell lung carcinoma No 2 2 2.90
Esophageal carcinoma No 4 2 1.37
Serous ovarian adenocarcinoma No 1 1 0.32
Pylocytic astrocytoma No 1 1 0.99
Diffuse B cell lymphoma No 1 1 4.35
Glioblastoma multiforme No 1 1 0.26
Medulloblastoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence