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KCNH8 has not been detected as a mutational cancer driver

KCNH8
Ensembl id ENSG00000183960
Mutated samples
Coding Sequence 130 (1.9%)
Protein Affecting 100 (1.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all KCNH8 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 26 21 5.69
Lung adenocarcinoma No 19 15 3.84
Stomach adenocarcinoma No 13 11 6.83
Lung squamous cell carcinoma No 12 10 5.75
Breast carcinoma No 6 5 0.44
Head and neck squamous cell carcinoma No 5 5 1.33
Colorectal adenocarcinoma No 5 4 1.75
Esophageal carcinoma No 5 4 2.74
Bladder carcinoma No 3 3 3.06
Serous ovarian adenocarcinoma No 3 3 0.95
Small cell lung carcinoma No 4 3 4.35
Glioblastoma multiforme No 4 3 0.79
Hepatocarcinoma No 3 2 2.22
Renal clear cell carcinoma No 2 2 0.48
Uterine corpus endometrioid carcinoma No 4 2 0.87
Multiple myeloma No 2 2 2.90
Lower grade glioma No 3 2 1.18
Acute myeloid leukemia No 1 1 0.51
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 8 1 0.34
Medulloblastoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence