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KCNH1 has not been detected as a mutational cancer driver

KCNH1
Ensembl id ENSG00000143473
Mutated samples
Coding Sequence 143 (2.1%)
Protein Affecting 89 (1.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all KCNH1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 42 22 5.96
Lung adenocarcinoma No 19 15 3.84
Lung squamous cell carcinoma No 12 9 5.17
Head and neck squamous cell carcinoma No 9 7 1.87
Breast carcinoma No 9 6 0.52
Small cell lung carcinoma No 6 6 8.70
Esophageal carcinoma No 8 5 3.42
Uterine corpus endometrioid carcinoma No 5 4 1.74
Stomach adenocarcinoma No 5 4 2.48
Glioblastoma multiforme No 4 4 1.06
Serous ovarian adenocarcinoma No 3 2 0.63
Colorectal adenocarcinoma No 3 2 0.87
Prostate adenocarcinoma No 1 1 0.41
Lower grade glioma No 1 1 0.59
Diffuse B cell lymphoma No 2 1 4.35
Hepatocarcinoma No 2 0 0.00
Bladder carcinoma No 4 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Non small cell lung carcinoma No 2 0 0.00
Chronic lymphocytic leukemia No 5 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence