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KALRN is detected as a mutational cancer driver in 1 cancer type: Head and neck squamous cell carcinoma and in the PAN-cancer analysis

KALRN
Ensembl id ENSG00000160145
Mutated samples
Coding Sequence 258 (3.8%)
Protein Affecting 184 (2.7%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
HNSC F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all KALRN gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma Yes 27 23 6.13
Breast carcinoma Yes 15 11 0.96
Small cell lung carcinoma Yes 6 5 7.25
Non small cell lung carcinoma Yes 5 3 9.68
Esophageal carcinoma Yes 4 3 2.05
Glioblastoma multiforme Yes 2 2 0.53
Cutaneous melanoma No 76 52 14.09
Lung adenocarcinoma No 21 18 4.60
Lung squamous cell carcinoma No 20 15 8.62
Uterine corpus endometrioid carcinoma No 16 13 5.65
Bladder carcinoma No 11 8 8.16
Stomach adenocarcinoma No 13 8 4.97
Colorectal adenocarcinoma No 9 7 3.06
Renal clear cell carcinoma No 5 5 1.20
Serous ovarian adenocarcinoma No 6 4 1.27
Chronic lymphocytic leukemia No 9 2 0.69
Hepatocarcinoma No 1 1 1.11
Medulloblastoma No 1 1 0.48
Neuroblastoma No 2 1 0.48
Multiple myeloma No 3 1 1.45
Lower grade glioma No 2 1 0.59
Prostate adenocarcinoma No 1 0 0.00
Acute myeloid leukemia No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence