IntOGen - JAK2 gene cancer mutations

JAK2 is detected as a mutational cancer driver

JAK2 reports

Methods
Mutation distribution

Gene details

JAK2
Ensembl ID ENSG00000096968 Transcript ID ENST00000381652 Protein ID ENSP00000371067
Cancer types where is driver 4 Cohorts where is driver 5 Mutated samples 27 Mutations 357
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence