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IRF2 is detected as a mutational cancer driver in 2 cancer types: Chronic lymphocytic leukemia, Stomach adenocarcinoma

IRF2
Ensembl id ENSG00000168310
Mutated samples
Coding Sequence 42 (0.6%)
Protein Affecting 34 (0.5%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
CLL F
STAD F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all IRF2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Stomach adenocarcinoma Yes 7 7 4.35
Chronic lymphocytic leukemia Yes 5 4 1.38
Cutaneous melanoma No 11 10 2.71
Head and neck squamous cell carcinoma No 4 3 0.80
Uterine corpus endometrioid carcinoma No 3 2 0.87
Serous ovarian adenocarcinoma No 2 2 0.63
Prostate adenocarcinoma No 1 1 0.41
Lung adenocarcinoma No 1 1 0.26
Bladder carcinoma No 1 1 1.02
Breast carcinoma No 1 1 0.09
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 2 1 0.26
Lung squamous cell carcinoma No 1 0 0.00
Small cell lung carcinoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence