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IRAK2 has not been detected as a mutational cancer driver

IRAK2
Ensembl id ENSG00000134070
Mutated samples
Coding Sequence 44 (0.6%)
Protein Affecting 35 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all IRAK2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 12 11 2.98
Lung adenocarcinoma No 6 6 1.53
Breast carcinoma No 5 5 0.44
Head and neck squamous cell carcinoma No 2 2 0.53
Prostate adenocarcinoma No 2 1 0.41
Bladder carcinoma No 2 1 1.02
Medulloblastoma No 1 1 0.48
Lung squamous cell carcinoma No 2 1 0.57
Thyroid carcinoma No 1 1 0.31
Uterine corpus endometrioid carcinoma No 1 1 0.43
Chronic lymphocytic leukemia No 2 1 0.34
Serous ovarian adenocarcinoma No 2 1 0.32
Stomach adenocarcinoma No 1 1 0.62
Colorectal adenocarcinoma No 1 1 0.44
Glioblastoma multiforme No 1 1 0.26
Pancreas adenocarcinoma No 1 0 0.00
Esophageal carcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence