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INPP4A is detected as a mutational cancer driver in 1 cancer type: Uterine corpus endometrioid carcinoma

INPP4A
Ensembl id ENSG00000040933
Mutated samples
Coding Sequence 66 (1.0%)
Protein Affecting 47 (0.7%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
UCEC F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all INPP4A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Uterine corpus endometrioid carcinoma Yes 9 9 3.91
Cutaneous melanoma No 12 7 1.90
Breast carcinoma No 9 6 0.52
Lung squamous cell carcinoma No 7 5 2.87
Head and neck squamous cell carcinoma No 8 5 1.33
Lung adenocarcinoma No 7 4 1.02
Renal clear cell carcinoma No 2 2 0.48
Serous ovarian adenocarcinoma No 2 2 0.63
Small cell lung carcinoma No 2 2 2.90
Bladder carcinoma No 1 1 1.02
Chronic lymphocytic leukemia No 3 1 0.34
Stomach adenocarcinoma No 1 1 0.62
Colorectal adenocarcinoma No 1 1 0.44
Esophageal carcinoma No 1 1 0.68
Prostate adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence