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IL12RB2 has not been detected as a mutational cancer driver

IL12RB2
Ensembl id ENSG00000081985
Mutated samples
Coding Sequence 60 (0.9%)
Protein Affecting 48 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all IL12RB2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 13 11 2.81
Head and neck squamous cell carcinoma No 7 7 1.87
Breast carcinoma No 4 3 0.26
Cutaneous melanoma No 3 3 0.81
Serous ovarian adenocarcinoma No 3 3 0.95
Esophageal carcinoma No 4 3 2.05
Hepatocarcinoma No 2 2 2.22
Lung squamous cell carcinoma No 3 2 1.15
Renal clear cell carcinoma No 2 2 0.48
Uterine corpus endometrioid carcinoma No 4 2 0.87
Colorectal adenocarcinoma No 2 2 0.87
Glioblastoma multiforme No 3 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Bladder carcinoma No 1 1 1.02
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Chronic lymphocytic leukemia No 2 1 0.34
Stomach adenocarcinoma No 2 1 0.62
Multiple myeloma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence