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IGSF10 has not been detected as a mutational cancer driver

IGSF10
Ensembl id ENSG00000152580
Mutated samples
Coding Sequence 215 (3.2%)
Protein Affecting 157 (2.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all IGSF10 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 75 54 14.63
Lung adenocarcinoma No 19 16 4.09
Stomach adenocarcinoma No 17 14 8.70
Breast carcinoma No 17 11 0.96
Head and neck squamous cell carcinoma No 12 8 2.13
Esophageal carcinoma No 9 8 5.48
Serous ovarian adenocarcinoma No 7 7 2.22
Lung squamous cell carcinoma No 9 6 3.45
Bladder carcinoma No 6 5 5.10
Renal clear cell carcinoma No 6 4 0.96
Uterine corpus endometrioid carcinoma No 7 4 1.74
Prostate adenocarcinoma No 5 3 1.23
Chronic lymphocytic leukemia No 4 3 1.03
Lower grade glioma No 4 3 1.78
Colorectal adenocarcinoma No 5 3 1.31
Hepatocarcinoma No 2 2 2.22
Small cell lung carcinoma No 3 2 2.90
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 2 1 1.45
Glioblastoma multiforme No 1 1 0.26
Pancreas adenocarcinoma No 1 0 0.00
Thyroid carcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence