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HTT has not been detected as a mutational cancer driver

HTT
Ensembl id ENSG00000197386
Mutated samples
Coding Sequence 148 (2.2%)
Protein Affecting 95 (1.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all HTT gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 47 31 8.40
Stomach adenocarcinoma No 12 11 6.83
Uterine corpus endometrioid carcinoma No 10 8 3.48
Lung squamous cell carcinoma No 9 6 3.45
Small cell lung carcinoma No 6 6 8.70
Head and neck squamous cell carcinoma No 9 6 1.60
Lung adenocarcinoma No 9 5 1.28
Breast carcinoma No 8 4 0.35
Prostate adenocarcinoma No 5 3 1.23
Bladder carcinoma No 5 3 3.06
Renal clear cell carcinoma No 4 2 0.48
Neuroblastoma No 2 2 0.95
Serous ovarian adenocarcinoma No 4 2 0.63
Colorectal adenocarcinoma No 4 2 0.87
Esophageal carcinoma No 2 2 1.37
Hepatocarcinoma No 2 1 1.11
Thyroid carcinoma No 2 1 0.31
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 4 0 0.00
Lower grade glioma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence