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HTR3C has not been detected as a mutational cancer driver

HTR3C
Ensembl id ENSG00000178084
Mutated samples
Coding Sequence 54 (0.8%)
Protein Affecting 40 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all HTR3C gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 15 10 2.71
Lung adenocarcinoma No 7 6 1.53
Lung squamous cell carcinoma No 6 5 2.87
Uterine corpus endometrioid carcinoma No 4 4 1.74
Thyroid carcinoma No 2 2 0.62
Lower grade glioma No 2 2 1.18
Colorectal adenocarcinoma No 2 2 0.87
Head and neck squamous cell carcinoma No 3 2 0.53
Esophageal carcinoma No 4 2 1.37
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 1 1 1.11
Serous ovarian adenocarcinoma No 1 1 0.32
Stomach adenocarcinoma No 2 1 0.62
Glioblastoma multiforme No 1 1 0.26
Breast carcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence