Top
HOOK1 has not been detected as a mutational cancer driver

HOOK1
Ensembl id ENSG00000134709
Mutated samples
Coding Sequence 54 (0.8%)
Protein Affecting 46 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all HOOK1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 13 12 3.25
Breast carcinoma No 7 7 0.61
Lung adenocarcinoma No 6 4 1.02
Bladder carcinoma No 3 3 3.06
Lung squamous cell carcinoma No 4 3 1.72
Head and neck squamous cell carcinoma No 4 3 0.80
Glioblastoma multiforme No 3 3 0.79
Medulloblastoma No 2 2 0.95
Uterine corpus endometrioid carcinoma No 3 2 0.87
Esophageal carcinoma No 2 2 1.37
Renal clear cell carcinoma No 1 1 0.24
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Stomach adenocarcinoma No 1 1 0.62
Colorectal adenocarcinoma No 1 1 0.44
Chronic lymphocytic leukemia No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence