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HMCN1 has not been detected as a mutational cancer driver

HMCN1
Ensembl id ENSG00000143341
Mutated samples
Coding Sequence 465 (6.8%)
Protein Affecting 371 (5.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all HMCN1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 80 63 17.07
Lung adenocarcinoma No 41 39 9.97
Breast carcinoma No 37 31 2.70
Stomach adenocarcinoma No 33 25 15.53
Head and neck squamous cell carcinoma No 28 23 6.13
Esophageal carcinoma No 27 21 14.38
Lung squamous cell carcinoma No 21 19 10.92
Renal clear cell carcinoma No 19 19 4.56
Glioblastoma multiforme No 28 19 5.01
Colorectal adenocarcinoma No 18 16 6.99
Bladder carcinoma No 17 15 15.31
Serous ovarian adenocarcinoma No 21 14 4.43
Uterine corpus endometrioid carcinoma No 17 13 5.65
Chronic lymphocytic leukemia No 15 8 2.76
Prostate adenocarcinoma No 13 6 2.47
Small cell lung carcinoma No 6 6 8.70
Neuroblastoma No 6 5 2.38
Pancreas adenocarcinoma No 4 4 1.87
Diffuse B cell lymphoma No 5 4 17.39
Acute lymphocytic leukemia No 4 4 3.28
Hepatocarcinoma No 4 3 3.33
Medulloblastoma No 3 3 1.43
Thyroid carcinoma No 3 3 0.93
Multiple myeloma No 4 3 4.35
Lower grade glioma No 5 3 1.78
Acute myeloid leukemia No 2 1 0.51
Non small cell lung carcinoma No 2 1 3.23
Pylocytic astrocytoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence