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HIST2H2AC has not been detected as a mutational cancer driver

HIST2H2AC
Ensembl id ENSG00000184260
Mutated samples
Coding Sequence 89 (1.3%)
Protein Affecting 22 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all HIST2H2AC gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 15 5 1.28
Thyroid carcinoma No 2 2 0.62
Cutaneous melanoma No 10 2 0.54
Head and neck squamous cell carcinoma No 8 2 0.53
Prostate adenocarcinoma No 2 1 0.41
Bladder carcinoma No 3 1 1.02
Breast carcinoma No 14 1 0.09
Lung squamous cell carcinoma No 7 1 0.57
Pancreas adenocarcinoma No 1 1 0.47
Uterine corpus endometrioid carcinoma No 3 1 0.43
Chronic lymphocytic leukemia No 2 1 0.34
Serous ovarian adenocarcinoma No 4 1 0.32
Stomach adenocarcinoma No 5 1 0.62
Diffuse B cell lymphoma No 2 1 4.35
Esophageal carcinoma No 2 1 0.68
Hepatocarcinoma No 2 0 0.00
Renal clear cell carcinoma No 3 0 0.00
Multiple myeloma No 1 0 0.00
Lower grade glioma No 2 0 0.00
Small cell lung carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence