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HEATR1 has not been detected as a mutational cancer driver

HEATR1
Ensembl id ENSG00000119285
Mutated samples
Coding Sequence 127 (1.9%)
Protein Affecting 87 (1.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all HEATR1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma No 17 15 1.31
Lung adenocarcinoma No 17 14 3.58
Cutaneous melanoma No 24 14 3.79
Uterine corpus endometrioid carcinoma No 8 7 3.04
Lung squamous cell carcinoma No 7 5 2.87
Colorectal adenocarcinoma No 6 5 2.18
Head and neck squamous cell carcinoma No 10 5 1.33
Bladder carcinoma No 3 3 3.06
Renal clear cell carcinoma No 4 3 0.72
Thyroid carcinoma No 3 3 0.93
Stomach adenocarcinoma No 8 3 1.86
Esophageal carcinoma No 3 3 2.05
Serous ovarian adenocarcinoma No 3 2 0.63
Small cell lung carcinoma No 2 2 2.90
Prostate adenocarcinoma No 1 1 0.41
Lower grade glioma No 3 1 0.59
Glioblastoma multiforme No 3 1 0.26
Hepatocarcinoma No 2 0 0.00
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence