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HDAC4 has not been detected as a mutational cancer driver

HDAC4
Ensembl id ENSG00000068024
Mutated samples
Coding Sequence 91 (1.3%)
Protein Affecting 58 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all HDAC4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 20 13 3.52
Lung adenocarcinoma No 12 9 2.30
Breast carcinoma No 6 5 0.44
Head and neck squamous cell carcinoma No 8 5 1.33
Lung squamous cell carcinoma No 6 3 1.72
Uterine corpus endometrioid carcinoma No 3 3 1.30
Stomach adenocarcinoma No 4 3 1.86
Hepatocarcinoma No 2 2 2.22
Bladder carcinoma No 3 2 2.04
Serous ovarian adenocarcinoma No 3 2 0.63
Small cell lung carcinoma No 3 2 2.90
Esophageal carcinoma No 4 2 1.37
Pancreas adenocarcinoma No 1 1 0.47
Renal clear cell carcinoma No 1 1 0.24
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 1 1 1.45
Colorectal adenocarcinoma No 2 1 0.44
Glioblastoma multiforme No 2 1 0.26
Chronic lymphocytic leukemia No 2 0 0.00
Lower grade glioma No 1 0 0.00
Pylocytic astrocytoma No 5 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence