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HDAC1 has not been detected as a mutational cancer driver

HDAC1
Ensembl id ENSG00000116478
Mutated samples
Coding Sequence 48 (0.7%)
Protein Affecting 19 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all HDAC1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma No 14 7 0.61
Lung adenocarcinoma No 2 2 0.51
Lung squamous cell carcinoma No 3 2 1.15
Renal clear cell carcinoma No 3 2 0.48
Cutaneous melanoma No 12 2 0.54
Bladder carcinoma No 1 1 1.02
Serous ovarian adenocarcinoma No 2 1 0.32
Stomach adenocarcinoma No 3 1 0.62
Colorectal adenocarcinoma No 3 1 0.44
Prostate adenocarcinoma No 1 0 0.00
Uterine corpus endometrioid carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Head and neck squamous cell carcinoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence