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HCN3 has not been detected as a mutational cancer driver

HCN3
Ensembl id ENSG00000143630
Mutated samples
Coding Sequence 90 (1.3%)
Protein Affecting 41 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all HCN3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 20 10 2.71
Breast carcinoma No 10 6 0.52
Uterine corpus endometrioid carcinoma No 7 5 2.17
Stomach adenocarcinoma No 6 5 3.11
Lung squamous cell carcinoma No 9 3 1.72
Bladder carcinoma No 4 2 2.04
Medulloblastoma No 2 2 0.95
Renal clear cell carcinoma No 4 2 0.48
Small cell lung carcinoma No 3 2 2.90
Prostate adenocarcinoma No 1 1 0.41
Lung adenocarcinoma No 8 1 0.26
Serous ovarian adenocarcinoma No 2 1 0.32
Head and neck squamous cell carcinoma No 3 1 0.27
Thyroid carcinoma No 1 0 0.00
Neuroblastoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Lower grade glioma No 2 0 0.00
Colorectal adenocarcinoma No 2 0 0.00
Glioblastoma multiforme No 3 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence