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GTF2A1L has not been detected as a mutational cancer driver

GTF2A1L
Ensembl id ENSG00000242441
Mutated samples
Coding Sequence 177 (2.6%)
Protein Affecting 58 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all GTF2A1L gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 54 18 4.88
Lung squamous cell carcinoma No 23 11 6.32
Lung adenocarcinoma No 14 4 1.02
Stomach adenocarcinoma No 17 4 2.48
Small cell lung carcinoma No 6 4 5.80
Colorectal adenocarcinoma No 7 4 1.75
Head and neck squamous cell carcinoma No 8 3 0.80
Hepatocarcinoma No 4 2 2.22
Bladder carcinoma No 3 2 2.04
Breast carcinoma No 11 2 0.17
Pancreas adenocarcinoma No 3 1 0.47
Uterine corpus endometrioid carcinoma No 6 1 0.43
Serous ovarian adenocarcinoma No 6 1 0.32
Diffuse B cell lymphoma No 1 1 4.35
Prostate adenocarcinoma No 1 0 0.00
Acute myeloid leukemia No 1 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 1 0 0.00
Glioblastoma multiforme No 3 0 0.00
Esophageal carcinoma No 7 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence